Research

Indonesian Prenatal Institute

Highlight of our studies since 2022

We are currently involved in a largest pre-eclampsia screening and prevention multi-center study in Asia. Regularly audited data and certified physicians are our concerns in order to obtain a high quality study.

ongoing studies
0
Deliveries Recorded
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Int'l Publications
0
Multicenter RCT
2

Surveillance

Safe Prenatal Surveillance is a data cohort collected by the Indonesian Prenatal Institute since 2018.  We have been collecting data from the early trimester of pregnancy until birth. This data has been regularly audited and has been used for more than 30 research projects that have influenced the decision-making process for screening and intervention to prevent pregnancy complications in our population in Jakarta and the greater area. One of our successful projects is Safe Prenatal PE, which has decreased almost 40% of pre-eclampsia in our population.  For further collaboration and data access, please contact us via info@prenatal.or.id.

Publications

  1. Ophthalmic artery Doppler for pre‐eclampsia prediction at the first trimester: a Bayesian survival‐time model. Raden Aditya Kusuma, Detty Siti Nurdiati, Adly Nanda Al Fattah, Didi Danukusumo, Sarini Abdullah, Ivan Sini. Journal of Ultrasound (2023) 26:155–162 pdf
  2. Alternatives of Risk Prediction Models for Preeclampsia in a Low Middle-Income Setting. 
    Raden Aditya Kusuma, Detty Siti Nurdiati, Siswanto Agus Wilopo. Open Access Macedonian Journal of Medical Sciences. 2022 Feb 05; 10(B):1-6 pdf
  3. Exploring First Trimester Maternal Risk Factors of Preterm Preeclampsia in Indonesia: Examining the Role of Education Level and Insurance. Status. Amanda S D Hertika, Adly N A Fattah, Felix F Widjaja, Shinda Marizni, Raden A Kusuma. Poster session presented at International Society for Prenatal Diagnosis (ISPD); 2023 Jun 19-21; Edinburgh, UK. pdf
  4. Performance of First-Trimester Combined Screening for Preeclampsia in Asian Population: A Systematic Review and Meta-analysis. Mirani Ulfa Yusrika, Raden Aditya Kusuma, Adly Nanda Al Fattah, Anastasya Maria Kosasih. Poster session presented at Pertemuan Ilmiah Tahunan Perkumpulan Obstetri dan Ginekologi Indonesia (PIT POGI); 2023 Jul 24-26; Yogyakarta, Indonesia. pdf
  5. Prevalence and Risk Factors of Stillbirth: Study on Pregnant Women in Indonesia. 
    Mirani Ulfa Yusrika, Raden Aditya Kusuma, Adly Nanda Al Fattah, Shinda Marizni, Vania Permata Putri, Felix Widjaja. XXIV FIGO World Congress of Gynecology and Obstetrics; 2023 October 9-12; Paris, France .pdf
  6. Bayesian Accelerated Failure Time Model and Its Application to Preeclampsia.Dennis Alexander, Sarini Abdullah. Proceedings of the International Conference on Mathematics, Geometry, Statistics, and Computation (IC-MaGeStiC 2021). pdf
  7. Reference range of placental growth factors at 11–14 weeks’ gestation in Indonesia. Detty Siti Nurdiatia, Aditya Kusuma, Adly Nanda Al Fattah, Nining Handayani. Placenta 145 (2024) 126–129 pdf
  8. Incidence and first trimester risk factors of stillbirth in Indonesia. Mirani Ulfa Yusrika, Adly Nanda Al Fattah, Raden Aditya Kusuma, Felix Firyanto Widjaja, Shinda Marizni and Vania Permata Putri. J. Perinat. Med. 2024; aop. pdf

  9. Incidence and Characteristics of Pregnancies with Reactive Hypoglycaemia in Indonesian. MP Mahindra, MP Mapindra, AN Al-Fattah, RA Kusuma, A David, S Hillman, D Siassakos. Oral session presented at British Maternal & Fetal Medicine Society Conference (BMFMS); 2024 Apr 25-26; Spine, Liverpool. pdf

  10.  A prediction model for stillbirth based on first trimester pre-eclampsia combined screening. Adly Nanda Al-Fattah, Muhammad Pradhiki Mahindra, Mirani Ulfa Yusrika, Muhammad Pradhika Mapindra, Shinda Marizni, Vania Permata Putri, Sadina Pramuktini Besar, Felix Firyanto Widjaja, Raden Aditya Kusuma, Dimitrios Siassakos. Int J Gynecol Obstet. 2024;00:1–8 pdf

Current Enrolling Studies

  1. First-Trimester Placental Growth Factor Combined Model as a Predictor of Stillbirth

    Principal Investigator: Mirani Ulfa, MD., Adly Nanda, MD., Felix Firyanto, MD.

    The purpose of this study is to evaluate the effectiveness of a first-trimester placental growth factor (PlGF) combined model in predicting the risk of stillbirth. By conducting this research, we aim to assess the accuracy and reliability of the PlGF-based model in identifying pregnancies at a higher risk of stillbirth during the early stages.

  2. First Trimester Maternal Risk Factors of Early-onset, Preterm and Term Preeclampsia in Indonesian Population

    Principal Investigator: Amanda Safira, MD., Adly Nanda, MD., Felix Firyanto, MD.

    The purpose of this study is to identify and analyze the maternal risk factors associated with early-onset, preterm, and term preeclampsia during the first trimester of pregnancy in the Indonesian population. Through comprehensive research, we aim to better understand the unique set of risk factors that contribute to different types of preeclampsia.

  3. Validation Study: First Trimester Prediction for Preeclampsia with The Addition of Ophthalmic Artery Doppler: A Bayesian Survival-Time Model


    Principal Investigator: Ibtisam Nasution, MD

    The purpose of this study is to validate the utility of incorporating ophthalmic artery Doppler measurements into a Bayesian survival-time model for predicting preeclampsia during the first trimester. By conducting this validation study, we aim to assess the enhanced predictive accuracy of the combined model in identifying the risk of preeclampsia early in pregnancy.

  4. Correlation Between Maternal Age, BMI with First Trimester PlgF Level in Indonesian Population

    Principal Investigator: Adly Nanda, MD, Siti Solichatul, MD

    The purpose of this study is to investigate the correlation between maternal age, body mass index (BMI), and the placental growth factor (PlGF) levels during the first trimester of pregnancy in the Indonesian population. Through this research, we aim to understand how maternal age and BMI may influence PlGF levels, a critical biomarker in pregnancy.

  5. Nuchal Cord: Incidence, Neonatal, and Delivery Outcomes

    Principal Investigator: Adly Nanda, MD, Shinda Marizni, RM

    The purpose of this study is to investigate the incidence of nuchal cord occurrences and their potential impact on neonatal and delivery outcomes. Through this research, we aim to analyze the prevalence of nuchal cord in various birth settings and its association with neonatal health and delivery complications.

  6. Validation Study: Alternatives of Risk Prediction Models for Preeclampsia in a Low Middle-Income Setting


    Principal Investigator: Shinda Marizni, RM

    This study aims to evaluate the effectiveness and accuracy of alternative risk prediction models for preeclampsia in a low middle-income setting. Through rigorous validation processes, the study aims to assess the models’ reliability in predicting and identifying preeclampsia risk within this healthcare context.

  7. Incidence of Preeclampsia Before vs After Implementation of Combined Screening


    Principal Investigator: Erlinda Restu, MD

    The purpose of this study is to compare the incidence of preeclampsia before and after the implementation of combined screening methods. By investigating this, we aim to assess the impact of the combined screening approach on the occurrence of preeclampsia.

  8. First Trimester PlGF Level and Placental-associated Adverse Pregnancy Outcome in Indonesia

    Principal Investigator: Adly Nanda, MD


    The purpose of this study is to examine the relationship between first-trimester placental growth factor (PlGF) levels and adverse pregnancy outcomes associated with placental dysfunction in Indonesia.

  9. Anxiety Scale of First Trimester Preeclampsia Screening Among Prengnant Women


    Principal Investigator: Saffana Hilmi, B.Sc

    The purpose of this study is to develop and validate an anxiety scale specifically tailored for assessing anxiety levels among pregnant women undergoing first trimester preeclampsia screening. Through this research, we aim to provide a reliable tool to measure the anxiety experienced by pregnant women during the early stages of preeclampsia screening.

  10. Prevalence and Risk Factors of Stillbirth in an Indonesian Setting

    Principal Investigator: Mirani Ulfa, MD., Adly Nanda, MD., Felix Firyanto, MD.


    The purpose of this study is to determine the prevalence of stillbirth and identify the associated risk factors within an Indonesian setting. Through extensive research, we aim to analyze the factors contributing to stillbirth occurrences comprehensively.

  11. First Trimester Maternal Characteristics as Risk Factors for Preterm Preeclampsia in Indonesia with Consideration in Level of Education and Type of Health Insurance

    Principal Investigator: Amanda Safira, MD., Adly Nanda, MD., Felix Firyanto, MD.


    The purpose of this study is to investigate the correlation between first-trimester maternal characteristics and the risk of preterm preeclampsia in Indonesia, while considering the variables of education level and type of health insurance. Through comprehensive research, we aim to identify specific maternal characteristics that may contribute to the development of preterm preeclampsia, while also examining the potential influence of education level and health insurance type.

  12. Ultrasound Fetal Biometrics and Estimated Fetal Weight: Development of New Standard for Indonesian Population


    Principal Investigator: Uweisha Eraz, MD

    The purpose of this study is to establish a new standard for ultrasound fetal biometrics and estimated fetal weight that is specific to the Indonesian population. Through rigorous data collection and analysis, we aim to create accurate and reliable reference values for fetal biometric measurements and estimated weight, considering the unique characteristics of Indonesian fetuses.

  13. Anxiety Scale of Non-Invansive Prenatal Test Screening Among Prengnant Women


    Principal Investigator: Shinda Marizni, RM

    The purpose of this study is to develop and validate an anxiety scale focused on assessing the anxiety levels experienced by pregnant women undergoing non-invasive prenatal test (NIPT) screening.

  14. Evaluating the Quality Improvement Project for Klinik Bidan Prenatal (A Midwifery-Led Care)

    Principal Investigator: Shinda Marizni, RM


    The purpose of this study is to sssess the impact of the Quality Improvement Project on maternal and neonatal health outcomes, including indicators such as pregnancy complications, maternal mortality and neonatal morbidity.

    More information: https://bidan.prenatal.or.id/quality-improvement/

  15. Longitudinal Study of the Ophthalmic Artery Doppler

    Principal Investigator: Aditya Kusuma, MD., Adly Nanda, MD.

    The purpose of this study is to comprehensively assess the changes in ophthalmic artery Doppler measurements over time. By conducting repeated measurements throughout the course of the study period, we aim to gain insights into the dynamic patterns of blood flow in the ophthalmic artery.

More detailed information, contact shinda@prenatal.or.id

 
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